Aleksandr Fomin, PhD

In 2014 in the framework of the project research on the effect of metal oxide coatings modified with osteostimulating calcium phosphate (hydroxyapatite) on the processes and phenomena occurring in biological fluids; research of structural and morphological changes at the contact boundary “coating – biomedia”; development of a research basis for the preparation and conduct of complex laboratory and clinical testing of implants with metal oxide biocompatible coatings and methods of evaluation of biocompatibility and osseointegration potential of coatings; determination of the corrosion behavior of the coatings of implant devices in contact with liquid biomedia and establishing the patterns of change in functional characteristics, in particular the corrosion potential, on the duration of contact interaction were conducted. The main results obtained are the data on a comprehensive study of phase-structural state, chemical composition, micro- and nanostructures of oxide coatings modified with hydroxyapatite nanoparticles. The contact boundary “coating – bone” was studied by scanning electron microscopy combined with energy dispersive X-ray analysis of chemical composition, as well as the boundary “coating - cells (osteoblasts)” by fluorescence microscopy; the principle of fractal-spectral evaluation of biointegration potential in tested types of coatings was developed; the research method of in vitro and in vivo implantation osteointegration potential of implant devices with tested types of coatings was developed; specialized implant designs for veterinary applications were developed; hematological and biochemical parameters of liquid biomedia were studied; a comprehensive assessment of the soft tissue (the presence of inflammation) was made; corrosion activity of titanium implant devices in the interaction with the liquid biomedia was studied.